CDKN2A and neoplasm: In the case of KRasG12V‐driven neoplasia in the lung, premalignant lung adenomas exhibited weak proliferation with elevated expression of the senescence biomarkers p16INK4A, p15INK4B, Dec1, and DcR2 as well as SAβG activity and formation of SAHFs, whereas senescence biomarkers were hardly observed in lung adenocarcinomas, instead staining positive for the proliferative marker Ki67, which implies the presence of OIS in premalignant lesions but not in the established, malignant disease [122].