Increased expression of PECAM-1 and subsequent BBB dysfunction may also lead to pathophysiological changes in neurological injury and disorders.59 It is known that neuroinflammation and disturbance of the brain barrier integrity have been implicated in the occurrence and development of several neurological diseases.60 Neurovascular dysfunction occurs when cell-cell junctions and cell-matrix signaling break down. This evidence concerns the gene PECAM1 and nervous system disorder.