Previously, SLC7A1 localization has been reported to the basolateral membrane of the polarized kidney epithelial (MDCK and HEK) cells (Kizhatil and Albritton 2002), while a decrease in its expression was observed during endothelial cell dysfunction related to chronic renal failure (Schwartz et al. 2006). This evidence concerns the gene SLC7A1 and chronic kidney disease.