RNF115 and gastric cancer: To further explore the role of RNF115 in the development and progression of gastric cancer, we constructed lentiviral knockdown vector, pLVX-shRNF115, and screened BGC823 cell lines for stable knockdown of RNF115. qRT-PCR and western blot analysis confirmed that the RNF115 mRNA and protein were significantly decreased in BGC823 cells, respectively (Supplementary Fig. S7a, b).