Nonetheless, in patients with an autosomal dominant history of atypical parkinsonism, TBK1 should be part of any atypical parkinsonism gene panel along with MAPT and GRN, and mutations in TBK1 suspected if other family members have ALS (which would not be seen in MAPT or GRN mutations). This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.