The tumor cells of relapsed CIRC tumors were positive for CK8, CK18, CAM5.2, AE1/AE3, EMA, vimentin, fascin, l-caldesmon, prolyl 4-hydroxylase 1, lysyl hydroxylase 3, and transglutaminase II, indicating the presence of a CIRC tumor (Table 1, Fig. 3). The gene discussed is KRT18; the disease is neoplasm.