Since ERG and FLI1 play a central role in maintaining endothelial cell homeostasis by regulating the key cellular processes, their concurrent downregulation is likely to have a significant harmful impact on the vasculature of SSc patients, including impaired neo‐angiogenesis, thrombosis, and endothelial to mesenchymal transition.2, 16, 55, 56, 57. Here, FLI1 is linked to systemic sclerosis.