In our current study, we noticed that HNSCC samples with high MB21D2 levels correlated with low p16/CDKN2A expression (Fig. S2B and S2C), which is one of the critical genetic features for senescent cells to re‐enter the cell cycle and start cell proliferation by RAS expression/activation [48]. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.