De novo, monoallelic variants in SCN2A (Nav1.2), SCN3A (Nav1.3), and SCN8A (Nav1.6) are linked to other DEEs, including Ohtahara syndrome and early infantile epileptic encephalopathy type 13 (EIEE13).5, 6, 7, 8. This evidence concerns the gene SCN3A and early-infantile DEE.