Further, a post hoc analysis of six Phase 3 trials (n = 2328) reported a significantly lower 1-year risk of cardiac events (arterial embolic and thrombotic events, haemorrhagic or ischaemic cerebrovascular conditions, MI, or other IHD) among men with pre-existing CVD initiating degarelix compared with GnRH agonist therapy. Here, GNRH1 is linked to myocardial ischemia.