Therefore, the number of macrophages in WAT during obesity could be dependent on the expression of adipocyte Ccl2. 12, 13, 14Loss of rictor, a crucial component of mTORC2 that played a role in growth and metabolism,15 could lead to overexpression of Ccl2 in the adipocytes.16 The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.