As demonstrated in Figure 1B and Table 1, elevated expression of POU5F1 predicted poor prognosis of OS in bladder cancer, breast cancer, colorectal cancer, esophageal cancer, gastric cancer, LIHC, head and neck cancer, lung cancer and other cancers, including ovarian cancer, cervical cancer, neuroblastomas, and pancreatic cancer. The gene discussed is POU5F1; the disease is colorectal cancer.