In addition, POU5F1 (HR = 1.64, p = .038) was identified as an independent risk factor for OS of LIHC through multivariate analysis, as were tumor stage (HR =1.51, p < .001), tumor invasion depth (HR = 1.51, p < .001), and distant metastasis (HR = 3.73, p = .026) (Table 4). This evidence concerns the gene POU5F1 and neoplasm.