Of note, animal models of erythropoietic protoporphyria suggest a role for ABCG2 in cytoprotective porphyrin transport [77], mirroring a likely protective role for ABCG2 as a physiological porphyrin transporter in hematopoietic stem cells [78]. Here, ABCG2 is linked to erythropoietic protoporphyria.