In a cohort of only G3 neoplasms (Ki67 > 20%), Carlsen and collaborators defined two different populations on the base of Ki67 index (21–55% and > 55%), finding that median PFS and OS were significantly longer for patients with a Ki-67 21–54% (P < 0.001); another parameter evaluated in the study was the grade of differentiation of the primary tumor: well-differentiated tumor had longer OS and PFS than poorly differentiated (P < 0.001) even in an all-G3 neoplasms cohort [15]. This evidence concerns the gene MKI67 and neoplasm.