Interestingly, KEAP1 mutated LUAD have significantly lower expression levels of RSAD2, IFIH1 and TMEM173 (Fig. 8d) and a significantly decreased infiltration with dendritic cells and CD4 + as well as CD8 + T cells (Fig. 8e), showing that NRF2 pathway activation favors the generation of an immune-evasive tumor microenvironment. Here, CD4 is linked to neoplasm.