Next, we confirmed the downregulated expression of BCYRN1 in 22 normal tissues and 111 glioma tissues (46 Grade I and II, 65 Grade III and IV) by RT-qPCR, and found that the expression of BCYRN1 was significantly lower in glioma tissue, especially reduced with advanced glioma grade (Fig. 1d, Table 1). This evidence concerns the gene BCYRN1 and central nervous system cancer.