Next, we confirmed the downregulated expression of BCYRN1 in 22 normal tissues and 111 glioma tissues (46 Grade I and II, 65 Grade III and IV) by RT-qPCR, and found that the expression of BCYRN1 was significantly lower in glioma tissue, especially reduced with advanced glioma grade (Fig. 1d, Table 1). Here, BCYRN1 is linked to glioma.