We discover after chemical injury to the murine eye that lineage-labeled Myh11+ vSMCs-PCs are capable of disembarking from the underlying injured retinal vasculature and phenotypically switching to myofibroblasts that produce copious collagen, a sine qua non of proliferative vitreoretinopathy (PVR)39,40. This evidence concerns the gene MYH11 and proliferative vitreoretinopathy.