Our clinical data showed that patients in the APOE4+ group demonstrated a tendency toward an increased risk of sepsis, because the occurrence of sepsis is affected by many factors, whether the APOE gene polymorphism is related to the occurrence of sepsis needs to be further explored in a more uniform background and more samples, and a significant correlation was found between APOE4+ patients and increased sepsis mortality compared with APOE4−. This evidence concerns the gene APOE and Sepsis.