APOE and Sepsis: APOE3 protects porcine proximal tubular cells from gentamicin-induced injury44 and have protective effect in Alzheimer's disease45, this is consistent with our research results, which show that the proportion of APOE E3/E3 genotype in sepsis subtype is significantly higher than that in the septic shock group, suggesting that the APOE E3/E3 genotype is protective.