MUC5AC and intrahepatic cholangiocarcinoma: When the relationships between the number of methylated genes and the clinicopathological parameters of ICC were examined among these 8 genes, an increased number of methylated genes was associated with male sex, lower T stage, BD or SD type, the absence of intraglandular and/or extraglandular mucin production, the absence of perineural invasion, the absence of BilIN, the presence of chronic liver disease, the absence of nodal metastasis, and lower TNM stage (Table 2).