When we analyzed the relationship between the number of methylated genes and IDH1/2 mutation (Supplementary Table 3), ICCs with > and ≤ 5/8 methylated genes showed IDH1/2 mutation at a frequency of 52.2% and 2.7%, respectively, Compared with low-methylated ICCs (≤ 5/8 methylated genes), high-methylated ICCs (> 5/8 methylated genes) were associated with histological subtype of the BD or SD type, the absence of intraglandular and/or extraglandular mucin production, the absence of BilIN, and venous invasion (Supplementary Table 4). The gene discussed is IDH1; the disease is Behcet disease.