DENND2B is down regulated by protein kinase D (PKD)18,37 which is transcriptionally regulated by the KRAS-NF-κB signaling cascade in pancreatic cancer, suggesting that Rab13 may be functioning in a DENND2B-independent mechanism when regulating EV secretion in KRAS-mutant cells38. This evidence concerns the gene KRAS and pancreatic neoplasm.