In Brca1co/co;p53+/co;WAP-Cre tumors, although p53 exon 5–6 was lost in all samples due to Cre-mediated deletion, which markedly accelerated tumorigenesis (Supplementary Fig. 1a), 11/16 tumors had LOH on the remaining wild-type allele of p53. The time to first tumor detection between the p53 LOH group and the group without LOH was not significantly different (Table 1). This evidence concerns the gene TP53 and neoplasm.