BRCA1 and neoplasm: Interestingly, a common amplification or deletion pattern of CNVs was only found in the tumor stage (476PT, 153PT, and 153LMT) but not in the premalignant stage (VMMG and 476MMG) (Supplementary Fig. 5a–e), which might indicate that Brca1 deficiency results in random genetic events by causing genome instability in the premalignant stage, whereas driver genetic events accumulate and become dominant later in tumor stage.