Considering the essential role of BRCA1 in maintaining genome integrity, it is believed that loss of BRCA1 causes random mutations in the genome7, which randomly activate oncogenes or inactivate tumor suppressor genes (TSGs) and can be accumulated in the specific contexts of individual ecosystems under Darwinian natural selection, promoting tumor initiation, formation, and metastasis. Here, BRCA1 is linked to neoplasm.