Moreover, this study demonstrated for the first time the presence of a significant correlation between circulating sCD36 and the index of hepatic expression of CD36 in NAFLD patients, suggesting that the increase in serum sCD36 values is largely due to the overexpression of CD36 observed in hepatocytes of these patients, supporting the hypothesis that the level of CD36 expression in the liver may contribute significantly to the circulating pool of sCD367. This evidence concerns the gene CD36 and metabolic dysfunction-associated steatotic liver disease.