NFE2L2 and metabolic dysfunction-associated steatohepatitis: In line with these findings, mice lacking Nfe2l2 (encodingNRF2) fed a MCD34,35 or HFD36 recapitulate many NASH features, suggesting a key role of NRF2 in preventing NASH progression, not only due to the activation of antioxidant genes, but also by modulating fatty acid metabolism in hepatocytes.