Also, another study reported that pro-apoptotic/lipotoxic signalling triggered by mixed lineage kinase 3 (MLK3) induces the release of Hep-EVs enriched in potent C-X-C motif chemokine ligand 10 (CXCL10) leading to monocyte-derived macrophages chemotaxis to the liver and may activate KCs during NASH progression65. Here, TBCE is linked to metabolic dysfunction-associated steatohepatitis.