An interesting fact from this study was that the subcellular distribution of CD36 in the membrane only persisted when these hepatocytes were cultured with high doses of insulin, suggesting that the chronic hyperinsulinemia characteristic of obese Zucker rats could explain the translocation of CD36 to the hepatocellular membrane and, therefore, contribute to hepatic steatosis. The gene discussed is INS; the disease is Hepatic steatosis.