Evidences suggest that in LPS-induced acute lung injury (ALI), phospholipase D2 (PLD2) promotes PTPN14-mediated dephosphorylation of VE-Cadherin and redistribution of VE-cadherin at adherens junctions is essential for the recovery of endothelial barrier function after an edemagenic insult9. The gene discussed is CDH5; the disease is acute lung injury.