Modified RALE score >3, oxygen saturation <93%, creatinine >100 μmol·L−1, neutrophils >8×109 L−1, age >40 years, chronic lung disease, CRP >40 mg·L−1, albumin <34 g·L−1, male, non-white ethnicity, hypertension, diabetes. The gene discussed is CRP; the disease is diabetes mellitus.