Furthermore, hormone receptor (HR)-positive breast cancer is known to be less aggressive and correlated with a better prognosis than HR-negative breast cancer, and breast cancer with amplification or high expression of human epidermal growth factor receptor 2 (HER2 +) is correlated with a poorer prognosis than HER2- breast cancer [25, 28–30]. The gene discussed is NR4A1; the disease is breast cancer.