Because they are candidate genes for blood pressure and play crucial roles in steroid hormone biosynthesis, thus having a further effect on hypertension, we designed and conducted this study to explore the relationship between genetic variations in CYP17A1 (rs4409766, rs1004467, and rs3824755) and CYP21A2 (rs2021783) and the sensitivity of Chinese Han women to PE. This evidence concerns the gene CYP21A2 and Hypertension.