CYP17A1 and Hypertension: Recent genome-wide association studies (GWAS) identified many genetic variants or chromosomal regions that are associated with hypertension, such as ATP2B1, CYP17A1, CYP1A2, SH2B3, CACNB2, TGFB2, MTHFR, CYP11B2, and ULK4 [14–17].