Among these DMP-DEG interactions, aberrantly expressed genes relevant to T cell biology, such as ANXA6, CCR7, CD274, CD4, CD48, IRAK2, JUND, and NFKB2, were observed to be part of the same PCHi-C interactome with CpGs that displayed differential DNA methylation in SSc patients (Fig. 5d–f). This evidence concerns the gene CD274 and systemic sclerosis.