To identify the specific pathways that were altered, we performed DAVID gene ontology analysis and observed that downregulated genes were enriched in such signaling pathways as T cell receptor, IL-2 production, Fc-γ receptor, and interferon-gamma, as well as genes associated with systemic lupus erythematosus and viral carcinogenesis (Fig. 3c). The gene discussed is IL2; the disease is systemic lupus erythematosus.