Further genotyping of our SSc cohort showed that the presence of risk alleles in SNP rs3792783 (TNIP1) correlated well with differential DNA methylation and gene expression of associated DMPs and DEGs, namely ANXA6, which has been described to be essential to CD4+ T cell proliferation via interleukin-2 signaling [85]. Here, IL2 is linked to systemic sclerosis.