Third, from the previous study by López-Isac and colleagues [15], four SSc risk variants, TNIP1 (rs3792783), GSDMB (rs9303277), IL12RB1 (rs2305743), and CSK (rs1378942), were identified to physically interact with ANXA6, CCR7, JUND, and ULK3, respectively, as well as with the genes in which the interacting SSc-DMPs, cg17239269 (TNIP1), cg19458020 (RARA), cg10808810 (LSM4), and cg11062629 (MPI), respectively, were located. The gene discussed is TNIP1; the disease is systemic sclerosis.