Specifically, the SSc-associated susceptibility loci TNIP1 (rs3792783), GSDMB (rs9303277), IL12RB1 (rs2305743), and CSK (rs1378942) were possible candidates that interacted with both DMPs, situated in TNIP1, RARA, LSM4, and MPI, respectively, and their associated DEGs, namely ANXA6, CCR7, JUND, and ULK3, respectively (Fig. 6b). The gene discussed is IL12RB1; the disease is systemic sclerosis.