First, we identified four SSc-DMPs, cg17239269 (TNIP1), cg19458020 (RARA), cg10808810 (LSM4), and cg11062629 (MPI), whose DNA methylation correlated with the expression of four distant SSc-DEGs, ANXA6, CCR7, JUND, and ULK3. Second, these interactions were identified to exist within the same interactome in healthy individuals by previously published promoter capture Hi-C data from CD4+ T cells [47]. The gene discussed is TNIP1; the disease is systemic sclerosis.