Furthermore, other motifs of TF complexes important to T cell biology, such as the BAFT-JUN-AP1 complex, shown to play a role in CD4+ T cell differentiation [52], and TFs of the ETS family, whose deletion in CD4+ T cells result in autoimmunity in mice [53], were enriched in the hypomethylated cluster (Fig. 1f). This evidence concerns the gene JUN and Autoimmunity.