CD4 and systemic sclerosis: Thirdly, utilizing previously generated promoter capture Hi-C (PCHi-C) data of healthy CD4+ T cells [47], we overlapped promoter-non-promoter interactomes with SSc-associated DMP-DEG pairs by first overlapping DEGs with annotated promoters in PCHi-C and then overlapping correlating DMPs with the interacting non-promoter PCHi-C fragments.