The total number of The Ki67+ cells was increased significantly in nasal epithelium from both patients with CRSr (6.50, 0–17.33, P = 0.002) and patients with CRSsNP (5.0, 1.0–41.33, P = 0.004) compared to controls (3.0, 1.0–6.0), but showed no significant difference between patients with CRSr and patients with CRSsNP (P > 0.999) (Fig. 3b). The gene discussed is MKI67; the disease is chronic rhinosinusitis without nasal polyps.