The ratio of p63+ cells to Krt5+ cells in nasal epithelium from controls(88.01%, 80.71–98.98%), patients with CRSsNP (87.50%, 43.30–97.56%), and patients with CRSr (88.89%, 0–99.35%) showed no significant difference (P = 0.548) (Fig. 4a). The gene discussed is KRT5; the disease is chronic rhinosinusitis without nasal polyps.