Patients with MALE were more affected by blood hypertension (91, p = 0.023) and hypercholesterolemia (85, p = 0.007), were more ex-smokers (64, p < 0.001) and had a significantly reduced ABI compared to those without MALE (p < 0.001), who had higher LDL-C levels (p = 0.001) and higher sortilin levels (p < 0.001). This evidence concerns the gene SORT1 and familial hypercholesterolemia.