HMOX1 and acute myeloid leukemia: The sFVA was non-covalently attached to the surface of DSPE-PEG lipid-biotin shell of the hybrid system and mesoporphyrin (SnMP), loaded into the PLGA core, resulted in targeted heme oxygenase-1 (HO-1) inhibition in acute myelogenous leukemia (AML) through SnMP.