MPL and gout: Specifically, febuxostat is a non-purine XO inhibitor used in the treatment of gout [64,65], eltrombopag is a TpoR agonist used to boost platelet counts in patients with idiopathic thrombocytopenia purpura (ITP) [66,84], and resveratrol is a potent antioxidant isolated from the V. vinifera grape that has been tested in numerous indications [67,85,86,87,88] The reduction of uric acid by febuxostat drives its efficacy in treating gout but as the enzymatic activity of XO also leads to the formation of reactive oxygen species (ROS), febuxostat can reduce oxidative stress in cells [89,90,91,92].