Interestingly, angiotensin II was established as the driving factor triggering the series of events that follow when total fluid intake is insufficient leading to a metabolic switch compromising health, the use of angiotensin converting enzyme (ACE) inhibitors for conditions like high blood pressure, obesity and chronic kidney disease became rather popular as a medication for many noncommunicable diseases. This evidence concerns the gene ACE and obesity due to melanocortin 4 receptor deficiency.