Using a Cre-loxP mouse model of hepatic specific Arid2 deletion (Arid2ko), in a context of chemically (DEN) or genetically (via TP53 deletion and RasG12D oncogene expression) induced carcinogenesis, the authors additionally demonstrated that ARID2 acts as a metastasis suppressor in HCC. This evidence concerns the gene TP53 and hepatocellular carcinoma.