A splicing variant of NME1 inhibits the metastasis of lung cancer cells by interacting with Inhibitor of nuclear factor Kappa-B Kinase subunit beta (IKKβ) in an isotype-specific fashion and regulating tumor necrosis factor alpha (TNFα)-stimulated Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling negatively [16]. The gene discussed is IKBKB; the disease is lung carcinoma.