Our data do not support the hypothesis that MTD has a synergistic effect on glioblastoma cells, ameliorating apoptosis, necrosis, and cellular senescence following TMZ treatment, although MTD itself, at high dose levels (>20 μg/mL), was apoptosis/necrosis-inducing, irrespective of the MGMT status of glioblastoma cells. This evidence concerns the gene MGMT and glioblastoma.