Aimed at addressing these questions, we conducted a study using the glioblastoma cell lines LN229 and A172 (both are p53 functionally active and MGMT lacking) and a MGMT transfected derivative of LN229 (LN229-MGMT-c12) as well as human fibroblasts (the telomerase immortalized, non-tumorigenic line VH10T). Here, MGMT is linked to glioblastoma.