Gene expression analysis, and subsequent gene ontology study, revealed that genes belonging to T cell receptor signaling pathway, TLR signaling pathway, and virus defense signaling pathway, such as TLR-5, TNFSF10/TRAIL (tumor necrosis factor (ligand) family, member 10/TNF-related apoptosis-inducing ligand), PPP1R1613/TIMAP (protein phosphatase 1 regulatory subunit 16B), SIAH1 (E3 ubiquitin protein ligase 1), PIK3IP1 (phosphoinositide-3-kinase protein 1) and IL-17 are significantly dysregulated in TBC and RA patients [83]. The gene discussed is PPP1R16B; the disease is rheumatoid arthritis.