In particular, it was found that, in RA patients, TLRs are increased in both peripheral blood monocytes (TLR-2 and 4), synovial fibroblast (TLR-3 and 7), and in synovial fluid macrophages (TLR-2 and 4) [35,36]. The gene discussed is TLR3; the disease is rheumatoid arthritis.