Using the GSE15471 and TCGA-Pancreatic adenocarcinoma (PAAD) datasets, we analyzed the clinical importance of TOP2A-associated genes (HDAC1, HDAC2, HMGB1, HMGB2, NFYA, NFYB, NFYC, and SP1). The gene discussed is SP1; the disease is pancreatic adenocarcinoma.