VHL and clear cell renal carcinoma: In clear cell renal cell carcinoma (ccRCC), miR-30c-2-3p and miR-30a-3p are downregulated in von Hippel-Lindau (VHL)-deficient cancer tissues, and both miRNAs specifically bind to hypoxia inducible factor-2α (HIF2A) and inhibit the expression of its transcripts [36].