Several examples of genes implicated in HCC tumorigenesis and/or sorafenib resistance that were up-regulated in the Huh7-R cells and down-regulated following fostamatinib treatment in both Huh7-R and HepG2 HCC cells include transforming growth factor beta 2 (TGFB2) [19,20], hypoxia inducible factor 1 alpha subunit (HIF1A) [21], intercellular adhesion molecule 1 (ICAM1) [22,23] and ETS proto-oncogene 1 transcription factor (ETS1) [24]. Here, HIF1A is linked to hepatocellular carcinoma.