NLRP3 and chronic kidney disease: The NLRP3 inflammasome is composed of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 [24], and it has been reported that inhibiting renal NLRP3 activation could significantly reduce renal inflammation and improve the renal functions involved in the development of chronic kidney diseases [25,26].