TRPM7 and cardiac hypertrophy: Transgenic mice with heterozygous deletion of TRPM7 kinase domain (TRPM7+/Δkinase) have cardiac hypertrophy, inflammation, fibrosis, decreased cardiac [Mg]i, elevated expression of cytokines (IL-6, -10, -12, and TNF-α), increased cardiac collagen and fibronectin content, and increased infiltration of macrophages [171].