Additionally, in 80% of pediatric high-grade gliomas, activation of the PI3-kinase/Akt/mTOR signaling pathway is observed, and the majority have mutations in the tumor suppressor gene TP53. Overexpression of p53 in these gliomas is correlated with a poorer five-year progression-free survival [39,40]. Here, TP53 is linked to central nervous system cancer.