The biogenesis of circMMP9 depends on the eukaryotic initiation factor 4A3 (eIF4A3), which binds to the MMP3 mRNA transcript, promoting its cyclization (EIF4A3-induced circRNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes GBM cell tumorigenesis) [127]. This evidence concerns the gene MMP9 and glioblastoma.