SFRP2 and glioblastoma: Another lncRNA, MIR22HG, which undergoes high overexpression either in GBM or glioma stem-like cells and represents the host gene of miR-22-3p and miR-22-5p, promotes GBM progression by activating Wnt/β-catenin signaling via the downregulation of the SFRP2 and PCDH15 genes [125].