Such research is not unprecedented; for instance, the importance of syndecan-1 in hepatoma cell migration and invasion has been demonstrated [58,103], and the role of certain miRNAs in the negative regulation of both syndecan-1 [104] and Ets-1 [105] expression has been described, albeit the root causes of these expressional changes during tumor progression remain to be elucidated in more detail (Figure 10). Here, SDC1 is linked to neoplasm.