Such research is not unprecedented; for instance, the importance of syndecan-1 in hepatoma cell migration and invasion has been demonstrated [58,103], and the role of certain miRNAs in the negative regulation of both syndecan-1 [104] and Ets-1 [105] expression has been described, albeit the root causes of these expressional changes during tumor progression remain to be elucidated in more detail (Figure 10). Here, SDC1 is linked to hepatocellular carcinoma.