SDC1 and carcinoma: The degree of syndecan-1 loss in carcinomas often correlates with histological grade and indicates poor prognosis, as shown in head and neck [38,39,40], hepatocellular [13,14], colorectal [41,42,43,44], cervical [45], pancreatic [46], renal carcinomas [47], and bladder [48] cancers.