Own studies on the tissue material from patients of different advancement of inflammatory changes (grading), as well as different stages of fibrosis (staging) in chronic hepatitis C (CH-C), showed a higher relative expression of IGF1Ea and IGF1Ec isoforms, class I transcripts, and total IGF1 mRNA in the CH-C as compared to the control. The gene discussed is IGF1; the disease is cryohydrocytosis.