IL6 and neoplasm: Other factors include proinflammatory cytokine production in tumor microenvironment (e.g., IL-6) [17], tumor-associated viruses (e.g., HPV, HCV) [31,49,112,165,179], prolonged hypoxia and stress hormones [71], and/or other hormones (testosterone, E2, dexa) [14,30,106,108].