DAPK1 and hyperphosphatemia: For that reason, it will now be of considerable interest to investigate the occurrence of this pathway from Pi to DAPK-1 and TPM in endothelium during hyperphosphataemia in vivo, especially in CKD in which the accumulation of procoagulant endothelial MVs is already known to be an important feature of uraemic hyperphosphataemia [41].