GHITM and Parkinson disease: Previous work indicated that TMBIM5 itself is required for proper mitochondrial morphology and interacts with mitochondrial cytochrome c [15] possibly through an interaction with coiled-coil-helix and coiled-coil-helix domain containing 2 (CHCHD2), which is a protein that is also localized in the intermembrane space of mitochondria that is linked to Parkinson’s disease [58].