CV-A8 was also reported to cause HA, but HA was not enrolled in the disease surveillance reporting system of China; in addition, multiple clinical phenotypes, including AFP, lamellar ichthyosis, respiratory disease, and other features, have been reported to be associated with CV-A8 infection; therefore, the burden of CV-A8-related diseases might have been underestimated, posing a threat to public health. Here, AFP is linked to lamellar ichthyosis.