When it comes to patients who have already developed colorectal cancer, data concerning clinical usefulness of NSAIDs are rarer; use of aspirin seems to improve survival particularly in patients with colorectal cancer harbouring PIK3CA mutations [27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42]. The gene discussed is PIK3CA; the disease is colorectal cancer.