Previously, two GWAS seeking to identify genetic susceptibility to COPD in the Caucasian population found two SNPs in the HHIP gene (rs1828591 and rs13118928) with consistent replications in three cohorts; however, the combined p-values did not reach levels of significance at the GWAS level (1.74 × 10−7 and 1.67 × 10−7) [7]. The gene discussed is HHIP; the disease is chronic obstructive pulmonary disease.