Significantly increased glomerular filtration markers such as serum creatinine and blood urea nitrogen, glomerular injury markers-i.e., albuminuria (albumin/urine creatinine ratio), and tubular injury markers-i.e., urinary lipocalin-2 (NGAL) were noted in Gdf15-/- mice compared with wild type controls, which indicates more severe kidney disease in knockout mice (Figure 2B). Here, GDF15 is linked to kidney disorder.