At the preselected mRNA level, the expression of the glomerular extracellular matrix proteins, matrix remodeling enzymes matrix metalloproteinase-7 and matrix metalloproteinase-9, as well as inflammation markers, was higher in anti-GBM-treated Gdf15-/- mice compared with WT mice on day 14 (Figure 4B). This evidence concerns the gene GDF15 and glioblastoma.