PIK3CA and breast carcinoma: Analysis of the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) dataset (Figure S6A, data taken from Curtis et al., 2012; Pereira et al., 2016) showed that FOXM1 expression is inversely correlated with PTEN expression, consistent with this model for the PI3K-Akt pathway regulation of FOXM1 activity.